Author: Aldiyarbek Nurlan
Editor: Merentsova Anastasia
Using a set of genetic epidemiological approaches, including Mendelian randomization (a genetic method for determining the causal relationships of modifiable effects on diseases) and genetic co-localization, the researchers built a causal network of 1002 plasma proteins for 225 human diseases. In doing so, they identified 111 presumably causal effects, 65 proteins on 52 diseases, covering a wide range of diseases.
This analysis can be used to confirm both the efficacy and potential side effects of new drugs, and to provide evidence to support existing drugs for other indications.
“This study lays a solid methodological foundation for future genetic research. The next step will be an analytical protocol that will be used in the early verification of the target drug by the pharmaceutical research staff, ”the researchers note. The authors hope that the results of this work will help in the further development of inexpensive, but at the same time, effective drugs.
Source: https://www.sciencedaily.com/releases/2020/09/200907112327.htm
