Author: Aldiyarbek Nurlan
Editor: Merentsova Anastasia
Fractured bones often require implants to stabilize and effectively heal the fractured bone. However, they can contribute to the development of serious bone infections, such as osteomyelitis, which can only be managed with long-term antibiotic treatment.
Mesenchymal stem cells, which are found in bone marrow and adipose tissue, have antimicrobial properties. The aim of the study was to investigate the therapeutic effects of adipose stem cells (ADSC) in combination with the antibiotic ciprofloxacin in an animal model of bone infection.
To achieve this, the researchers first focused on the effect of ciprofloxacin on ADSC and found that the antibiotic did not affect stem cell function or viability. The researchers then tested the antimicrobial activity of the antibiotic-containing ADSCs in vitro (in vitro) and found that they were effective in reducing the growth of S. aureus bacteria, which is also the main microorganism that causes infections associated with bone implants.
“These are striking results that show how ADSC is more effective with antibiotics for potent antimicrobial effects. Our results suggest a potential new therapy for implant-associated osteomyelitis, for which conventional antibiotic treatment is usually insufficient,” – the researchers said.
Source: https://www.sciencedaily.com/releases/2020/10/201001113531.htm
