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Stem cells were collected in just two days

A team of researchers has developed a thermosetting platform for cell culture with nanotopography.

Author: Aldiyarbek Nurlan 

Editor: Merentsova Anastasia 


Stem cells are cell factories that continually divide to create new cells. Implanting stem cells into damaged organs can regenerate new tissue. 


The joint research team significantly reduced the total harvesting period of the stem cell leaf to two days. Nanotopography of poly (N-isopropylacrylamide) (PNIPAAm), which sharply changes its roughness with temperature, allows the collection of cell layers consisting of mesenchymal stem cells derived from bone marrow. 


The research focused on converting stem cells into sheets in a short time to increase their beneficial properties. The team achieved this by applying an isotropic pattern of 400 nm nanopores to the surface of a 3D 3D PNIPAAm. As a result, not only the formation and maturation of mesenchymal stem cells derived from human bone marrow was accelerated, but also the surface roughness of the bulk PNIPAAm at room temperature below the lower critical mark was rapidly reduced, effectively inducing detachment of cell sheets, which, in turn, made it possible to quickly collect the sheets. mesenchymal stem cells from human bone marrow. 


“We have significantly reduced the collection time by introducing nanotopography onto the surface of the 3D 3D PNIPAAm. As a result, sheets of mature stem cells were obtained for the first time in the world. We have the opportunity to apply the sheets directly to patients in the future, ”added the researchers.