Author: Aldiyarbek Nurlan
Editor: Kigbaeva Kamila
S. aureus is one of the most common bacterial infections worldwide. Antibiotic-resistant strains, such as methylene-resistant S. aureus (MRSA), pose a significant public health threat and burden. At the same time, MRSA affects not only immunocompromised individuals, but also healthy people.
Researchers have developed a new vaccine called 4X-SA-GP, which consists of mushroom glucan particles containing four S. aureus proteins. Mice were vaccinated once a week for three weeks with 4X-SA-GP and then injected with S. aureus after four or eight weeks. Vaccination induced a protective response of antibodies and T cells, which, in particular, played a critical role in protecting against staphylococcal infection. Moreover, the mice showed high levels of antibodies and decreased levels of S. aureus in the spleen and kidneys eight weeks after immunization.
According to the authors of the work, new creative approaches to the development of a vaccine against S. aureus, in particular, the experiment with antigen-loaded particles of fungi, may be a solution to the age-old problem of fighting this infection.
Source: https://www.sciencedaily.com/releases/2020/08/200820143237.htm
