Author: Vishnevskaya Karina
Translator: Issabayeva Madina
Copy editor: Kigbaeva Kamila
A randomized clinical trial was conducted, which included 71 supervised patients. This study shows that intestinal worms induce immune responses that can protect against multiple sclerosis (MS).
The aim of the study is to determine whether ankylostoma treatment has an impact on the activity of magnetic resonance tomography (MRI) and T-regulatory cells in recidivism RS. Randomized placebo-controlled research was conducted in a modified population, the Royal Medical Center of the University of Nottingham.
Patients aged between 18 and 61 with recurring RS (multiple sclerosis) were recruited from the RS clinic. They have been randomized to produce either 25 Necator Americanos larvae transcutaneous or placebo. MRI scans were conducted monthly for 3-9 months during treatment and 3 months after treatment.
The results of the patients were randomized to produce ankylostoma (genus parasitic roundworms). Sixty-six patients completed the study. The median of the cumulative number of new increases and increases in lesions did not differ reliably between the groups of the pre-planned Mann-Whitney U-tests, which lost strength in the data binding (the high number of MRI of zero activity in the group of ankylose versus the placebo group).
The percentage of cells increased by nine months in the group of ankyloses where placebo was used. No patient refused treatment because of side effects. There was no difference in undesirable phenomena between groups, except for the more discomfort of the skin at the place of the ankylost in the group.
There were five relapses in the group, against those receiving placebo. The conclusion was that ankylostoma treatment was safe and well tolerated. The primary outcome was not significant, probably due to the low level of disease activity.
The ankylostoma infection increased the number of T-regulatory cells, indicating the immunobiological effect of ankylostoma. It appears that the living organism can cause immunoregulatory changes that can affect the activity of RS disease.
Source: https://jamanetwork.com/searchresults
