Author: Bolysbek Dana
Editor: Kigbaeva Kamila
For ten years, scientists have been investigating the effect of oxytocin on bone metabolism. The purpose of their work was to study the principles of prevention and treatment of osteoporosis in women during the period of perimenopause (the period of large hormonal fluctuations in the woman's body). This condition is accompanied by a gradual decrease in bone density: bones become more fragile, which increases the risk of fractures and the development of diseases of the skeletal system.
The study involved ten female rats at the stage of periestropause (analogous to perimenopause in women) and a control group of rats of the same age. For 35 days, the hormone oxytocin was injected twice a day with an interval of 12 hours. Next, the scientists examined samples of their blood and femoral neck tissue and compared them with samples taken from rats who were not injected with the drug.
The animals treated with the hormone did not show signs of osteopenia (decreased bone density and mass), in contrast to the control group that did not receive the hormone. Their bones were denser and less porous. The blood showed a high activity of the enzyme alkaline phosphatase, which is responsible for maintaining bone density, and a decrease in the activity of tartrate-resistant acid phosphatase, which indicates the destruction of bone tissue.
The study was a big step towards the prevention and treatment of osteoporosis. In the future, it is planned to study the effect of oxytocin on bone metabolism in the human body. This will require a lot of research on the safety and effectiveness of the drug. Only after the implementation of which it will be possible to conduct clinical trials.