Author: Kasym Kasymkhan
Translator: Turarova Aiym
Copy editor: Kamila Kigbaeva
Scientists have noticed a violation of the expression of The zeb2 protein, which affects the integrity of the intestinal wall and epithelium. The epithelium serves as a protective barrier. The Zeb2 protein breaks down the barrier and intestinal bacteria, penetrating the tissues, causes inflammation, thereby increasing the risk of cancer. Researchers have found that early removal of the microbiota can prevent cancer. Experts also do not exclude the influence of environmental factors, sedentary lifestyle and obesity, which increase the likelihood of colorectal cancer.
Research groups have demonstrated how abnormal expression of the Zeb2 protein causes colorectal cancer in mice. A malignant tumor develops with abnormal proliferation of intestinal epithelial cells. When growing mice in absolutely sterile conditions or using broad-spectrum antibiotics, the risk of developing cancer is reduced to a minimum.
According to scientists, the interaction of the tumor-immune system-microbe can be useful for finding new methods of preventing and treating colorectal cancer. When exposed to a specific component of the immune system, you can get an effective method of treating colon cancer.
Source: https://www.eurekalert.org/
