Author: Merentsova Anastasia
Translator: Issabayeva Madina
Copy editor: Kigbayeva Kamila
Scientists at Princeton University created the SCH-79797 compound, which has a bactericidal effect (killing bacteria) on both gram-negative and gram-positive bacteria. This is facilitated by the unique mechanism of dual action of the substance - it can simultaneously pierce the walls of bacteria and destroy folic acid in their cells.
The research director, Professor Zemer Gitai, compares SCH-79797 with the "poisoned arrow" - a combination of two weapons - poison and a blade. The ability of this substance to «attack» from both inside and outside gives the opportunity to destroy any bacteria, including those resistant to all known antibiotics, such as staphylococcus and racing.
Bacteria do not form SCH-79797 resistance. For example, bacteria have been exposed to the drug for 25 days by researchers, with bacteria having a new generation approximately every 20 minutes. For their experiments, scientists used even the most stable strain of gonococcal Neisseria gonorrhoeae, which is among the top five most difficult to treat pathogens. As a result of the resistance experience, bacteria did not develop, unlike other antibiotics that scientists used to compare, where resistance was developed very quickly.
"It really looks promising, so we called it "Irresistine"' says the scientist. This antibiotic, which does not form resistance in bacteria, acts on even the most difficult antibiotic-resistant microorganisms and, according to scientists, is safe for humans, could in the future be a solution to the global health crisis and, of course, save a lot of lives.
Source: https://www.cell.com/cell/pdf/
