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Simulating SARS-CoV-2 infection, through the nose, in monkeys

Editor: Ahmetova Aigerim 

Translator: Tursunova Balkadisha 

Author: Aldiyarbek Nurlan 



The first step in all effective COVID-19 control and vaccine development is to understand the viral infection process. To achieve this goal, an effective animal model of SARS-CoV-2 infection is needed. In a new study, researchers developed a rhesus macaque model that mimics a natural infection through the nose. Rhesus macaques showed similar clinical and pathological manifestations of COVID-19 observed in humans. 


The results showed the spread of the SARS-CoV-2 virus and the release of the virus offspring, after successful reproduction, into the nose and stool for up to 27 days. This pattern of prolonged viral discharge in rhesus macaques is strikingly similar to that seen in humans. Researchers observed similar pathological changes between humans and rhesus macaques as they progressed from mild to severe interstitial pneumonia, an inflammatory condition that affects the tissues and space around the air sacs of the lungs. The results also revealed immune responses involving T cells that contributed to the progression of COVID-19, and inflammatory molecules that transmit cellular signals called inflammatory cytokines in the Airways. 


The clinicians conclude that their study of " nasal infection in rhesus macaques revealed an immune response and the pathological process of COVID-19."