Author: Akhmetova Aigerim
Editor: Merentsova Anastasia
Coronavirus disease 2019 (COVID-19) in humans is often clinically mild, but some people develop severe pneumonia, respiratory failure, and death: some people develop severe respiratory syndrome, while others have a clinically mild illness. This respiratory syndrome has been well studied in rodents.
The study recruited 70 Syrian hamsters. Intranasally, they were introduced, the causative agents of Covid-19. In the group with high doses of the pathogen injection, four animals died on the 2nd day, four - on the 4th day, 8 - on the 8th day. All remaining animals were dissected on the 14th day. In total, two hamsters recovered on day 14, which belonged to the group of low doses of pathogens.
High-dose intranasal administration of SARS-CoV-2 (causative agent Covid19) in hamsters has resulted in severe clinical disease, including high levels of viral replication in tissues, extensive pneumonia, weight loss and mortality in a subgroup of animals. But a single immunization with this vaccine caused binding and neutralization of antibody responses and protected against SARS-CoV-2-induced weight loss, pneumonia and death.
It can be concluded that a single immunization with Ad26-S provides reliable protection against the severe clinical course of the disease, but again, more trials are needed.
Source: https://pubmed.ncbi.nlm.nih.gov/32884153/
