Author: Akhmetova Aigerim
Editor: Merentsova Anastasia
At the moment, scientists around the world are studying the protective properties of innate immunity in the fight against COVID-19. Innate immunity is the body's ability to neutralize foreign and potentially dangerous agents (tumor cells, toxins, various microorganisms). The protective properties of this type of immunity are in an active state even before the first entry of this biomaterial into the body.
It is known that "trained" myeloid cells, which play a primary role in innate immunity, exhibit protective properties for many months or even years. How is this possible? - was unknown until the scientist de Laval conducted a series of experiments using mouse models, he showed that long-term induction (stimulation) of innate immune memory is generated by reprogramming myeloid precursors (hematopoietic stem cells) in the bone marrow.
It is also known that the anti-tuberculosis vaccine BCG, according to some epidemiological studies, due to the action of myeloid cells, is able to reduce the incidence of other infections. It is this property of the vaccine that scientists are going to use as a preventive measure in the fight against COVID-19.
Several studies are currently underway on the above topics. According to scientists, there is a fairly high probability that the results of the tests carried out can help to identify the role of trained immunity in the prevention of not only COVID-19, but also other infectious diseases.
Source: https://pubmed.ncbi.nlm.nih.gov/32905684/
