Author: Tursunova Balkadisha
Editor: Merentsova Anastasia
High prevalence of vitamin D intake can also lead to overdose. For a detailed description of such cases, a real clinical situation was taken as an example. In their report, the authors of the study "Targeted drugs for the treatment of immune disorders Endocr Metab" Sarah De Vincentis, Antonino Russo and other scientists described the toxic effect of vitamin D in excess of its content in the human body.
A 56-year-old woman was admitted to the hospital with complaints of nausea, vomiting, and muscle weakness for 3 weeks. From the medical history, the patient took a high dose of cholecalciferol for the treatment of multiple sclerosis. Before starting vitamin D administration, serum calcium and phosphorus levels were normal, and 25OH-vitamin D levels were very low (12.25 nmol / l). Upon admission, hypercalcemia (3.23 mmol / l) and acute kidney injury (eGFR 20 ml / min) were detected, associated with high concentrations OF 25oh-vitamin D (920 nmol / l), which confirmed the suspicion of vitamin d intoxication. Vitamin D intake was stopped, and hypercalcemia returned to normal after a week.
Thus, the consumption of high doses of Vitamin D can lead to intoxication of the body. However, the doses used in clinical practice for the prevention and / or treatment of vitamin D deficiency are significantly low compared to this clinical case. However, patients and doctors should be aware of the consequences of excessive consumption of this drug.
Source: https://pubmed.ncbi.nlm.nih.gov/33030138/
