Author: Aldiyarbek Nurlan
Editor: Merentsova Anastasia
Monoventricular heart or monoventricular circulation is a severe congenital heart anomaly, characterized by the presence of one functional chamber. Clinical manifestations include congestive heart failure, developmental delay, cyanosis, hypoxemia, and neurodevelopmental disorders.
According to the results of a small pilot study, the drug used to treat gout, probenecid, can improve the functional state of the heart in people with congenital heart defects (CHD), in particular those with the above pathology.
Researchers conducted a randomized, double-blind study that included eight participants with congenital heart disease and underwent palliative heart surgery. Each participant received probenecid or placebo over a 12-week period.
As a result of the pilot study, the participants improved the state of the cardiovascular system, the clinical symptoms characteristic of this pathology were leveled, in particular, the contractility of the heart muscle became better. Also, physical activity has become easier to tolerate by patients with this pathology.
“We can use this drug, long used to treat gout, to improve heart function in children with monoventricular circulation without any side effects,” the researchers said.
Source: https://www.sciencedaily.com/releases/2020/08/200827122117.htm
