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Scientists have found a way to restore lost teeth

Cell-free molecular therapy shown to be effective in dental regeneration

Editor: Bolysbek Dana

Author: Akhmetzhanova Inara

Translator: Tulkibaeva Nursulu


The standard number of teeth in humans is 32, but this can vary depending on genetics. Scientists from Kyoto University and Fukui University have discovered molecules that help dental regeneration in people with congenital dental agenesis.

Tooth agenesis is a congenital pathology, inherited where premolars and incisors are often missing.

Scientists used the USAG-1 gene, which affects tooth growth, and monoclonal antibodies used in cancer treatment.  The method showed efficacy in mice and ferrets the first time it was used. Ferrets, just like humans, first grow their milk teeth and then their permanent teeth. Scientists plan to conduct studies on other animals to understand all aspects of this method.

This study is the first to demonstrate the benefits of monoclonal antibodies in dental regeneration and provides a new therapeutic framework for a clinical problem that currently can only be solved with implants and other artificial measures.